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Since then, multiple guidelines and regulatory documents have addressed the issue, including a 1993 guidance on the study and evaluation of gender difference in clinical trial evaluation of drugs, which lifted restriction on participation by most women with childbearing potential (FDA, 1993, 2020b)

But are they a replacement for dietary intervention

Wear non-chemical sunscreen to protect skin from UV rays, and avoid vigorous exercise (especially swimming) for 24 hours or more

common and widely used in cheaper supplements