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As a food-derived dietary supplement, they are generally well tolerated, but a healthcare professional should still be consulted first

The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)

Dermal melasma is considered the most difficult to treat, as the pigment lies deeper in the skin

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Mater Sci Eng C Mater Biol Appl