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Factors affecting potassium levels Potassium physiology Approximately 98% of total body potassium is stored intracellularly, while 2% is in serum.[9] In normal kidney function, the kidney is responsible for approximately 90% of potassium excretion, while colonic excretion accounts for approximately 10%.[10] This intra- and extracellular difference in potassium levels is maintained by several complex mechanisms, including sodiumpotassium pumps and hormonal regulation

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