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P values indicated, calculated by two-way ANOVA with dks multiple comparisons test ( b, d )

PLoS One 9 (2), e89881

Why Combining Both Pathways Produces Synergistic Results Because GHRH-pathway compounds (CJC-1295) and GHS-R-pathway compounds (ipamorelin) act through entirely separate receptor systems, using both together generates effects larger than either alone