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Although there was no significant difference in Fe 2+ chelating ability between A-CDs and AA-CDs, AA-CDs with more surface acetylation modifications exhibited higher chondrocyte internalization efficiency

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Arsova B, Hoja U, Wimmelbacher M, Greiner E, stn , Melzer M, Petersen K, Lein W, Bornke F (2010) Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana

These molecules build up over time through a process called oxidation, and they can speed up cell aging and cause pre-mature cell damage