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Peroxisome-proliferator-activated receptors (PPARs) are transcription factors that are activated by endogenous fatty acids and fatty acid derivatives

Sun exposure is the largest environmental accelerant of skin aging, primarily through UV-driven DNA damage in keratinocytes and free radical generation that degrades collagen

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The most common use of milk thistle is for liver health

A more conservative approach may be worth discussing with a provider if you have a history of GI sensitivity or conditions like IBS, have previously stopped GLP-1 therapy because of side effects, are an older adult (who may be more sensitive to GI effects), or are starting treatment at a lower BMI where the full therapeutic dose may not be necessary