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Cafe-au-lait macules may also be associated with Albright's syndrome (polyostotic fibrous dysplasia, endocrine dysfunction, precocious puberty, cafeau- lait macules)

Wynn RL, Meiller TF, Crossley HF

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The implications of the occurrent process are the formation of cysts in ovaries, decrease ovarian follicles quality, and infertility ( In another study, patients were divided into two groups: with PCOS and without PCOS (control group) ( 5 Treatment of HT According to the study by Vickery and Hamlin, many patients do not require treatment, as the disease is often asymptomatic and the goiter is small (98)