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doi:10.1093/geront/gnz009

The United States Food and Drug Administration (FDA) approved it to treat obesity

However, heterogeneity was considerably reduced vs placebo in a sensitivity analysis excluding one trial with short duration and one trial in which all participants were on background insulin therapy

This synthetic hormone may overstimulate progesterone receptors in sensitive tissues, particularly in the brain and spinal cords protective layers known as the meninges, leading to abnormal cell growth and the formation of brain tumors, including a potential increase in glioma risk

Understanding survodutide vs retatrutide vs tirzepatide is essential for researchers navigating this rapidly evolving field in 2026