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Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16

Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols

TABLE 1 The scoring criteria of DAI

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The GSH and -GC concentrations (mg/L) of the sample were measured using the 4-fluoro-7-aminosulfonylbenzofurazan (ABD-F) derivatization method (Additional file 1: Figure S5) according to a previous report [29] with the reduced GSH as the standard