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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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In T2DM, elevated LC3-II and p62 levels suggest that autophagic flux is active but may be dysfunctional due to inefficient degradation of the autophagosomes

In children with documented growth hormone deficiency, it stimulates the pituitary to secrete GH through the body's own feedback mechanisms rather than replacing GH directly