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In that study, the authors further utilized pharmacology and mouse genetics to provide complementary evidence supporting a role for attenuation of CNS GIPR signalling in the enhancement of the weight loss effects induced by the GLP-1R agonist dulaglutide 61

GLP-1 RAs also exhibit protective effects against cardiovascular and renal complications, making them integral to comprehensive metabolic disease management (6)(15)

2020;31(11891205):e13

Avoid magnesium oxide, which has poor absorption and less laxative effect

Preclinical models using GLP-1estrogen conjugates have shown superior outcomes in metabolic regulation, neuronal viability, and hypothalamic signaling, with reduced systemic estrogenic effects