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Other cases in side-effects resulting from the administration of GLP-1 drugs without adequate In contrast to bariatric surgery, which use either purely restrictive (banding / balloon interventions), or malabsorptive and restrictive (gastric bypass, duodenal switch and sleeve gastrectomy procedures) methods to produce weight loss, GLP-1 receptor agonists (GLP-1s) significantly suppress appetite by multiple mechanisms (both centrally and peripherally) via the following known methods: Increased insulin secretion (lowering blood glucose) and inhibition of glucagon release Appear to cross the blood brain barrier, target the hippocampus and affect feeding behaviour Slow gastric emptying and hence, enhance the feeling of 'fullness' These actions result in: Rapid and occasionally uncontrolled weight loss

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Therefore, this research will be very helpful in the screening and development of new injectable drugs