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The Lancet Commission has identified numerous modifiable risk factors, including hypertension, diabetes, physical inactivity, and air pollution, that significantly contribute to the disease burden, in addition to aging (6)

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NAC, IFN-, and IFN-+NAC altered several common metabolic pathways in 12Z cells, including the Warburg effect, malate-aspartate shuttle, glutamate metabolism, urea cycle, glucose-alanine cycle, arginine-proline metabolism, citric acid cycle, alanine metabolism, galactose metabolism, carnitine synthesis, beta-alanine metabolism, and acetyl group transfer to mitochondria (Fig

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