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Conclusions and perspectives While a major function of the ascorbateglutathione cycle is the policing of H 2 O 2 signalling in the different subcellular compartments and also the intensity of the cell-to-cell ROS signalling wave, it also maintains the essential and multifaceted functions of ascorbate and GSH in plants

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Our results reveal the existence of residue networks crucial for unimolecular agonist-mediated receptor activation and their distinct signaling patterns, which might be useful to the rational design of biased drug leads

Atrial Natriuretic peptide attenuates colitis via inhibition of the cGAS-STING pathway in colonic epithelial cells

The authors propose a model for type 2 diabetes that assumes gradual decline in -cell function or mass over time in people at risk for developing type 2 diabetes