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Baseline and periodic measurement of vitamins A, D, E, and K may be warranted in patients with documented malabsorption

However, further research is necessary to elucidate the underlying molecular mechanisms and validate the efficacy of NAC in clinical settings

SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials

For most patients, fatigue improves within several weeks to a few months as the body adapts to treatment

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