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Patients with a personal history of pancreatitis, gallstones, or significantly elevated triglycerides should ensure their prescribing clinician or trial team is aware of these risk factors before commencing treatment

Key safety concerns associated with unregulated peptide use include: Hypoglycaemia GLP-1 and GIP receptor agonists have a low intrinsic risk of hypoglycaemia when used alone, but this risk increases significantly if combined with insulin or sulfonylureas

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The use of prazosin, an 1-adrenergic receptor blocker, showed that the ability of GLP-1RAs to reduce TNF- in plasma was disrupted, signifying the vital role of 1-adrenergic receptors in the anti-inflammatory action of GLP-1RAs