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For MS, protein bands were excised from the gel and subjected to in-gel digestion with trypsin

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In vitro co-immunoprecipitation and fluorescence polarisation assays have investigated the binding affinity of Proxofim for the p53 interaction domain, examining whether the DRI construct competitively displaces endogenous FOXO4 from the FOXO4-p53 complex in senescent fibroblast cultures

All formulations are prepared under strict Current Good Manufacturing Practice (CGMP) standards and can be incorporated into a broader care plan