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Chronic Disease Management Glutathione deficiency may be caused by HIV/AIDS, cancer, type 2 diabetes, Parkinson's disease, or hepatitis conditions that both deplete glutathione and are worsened by its depletion

10.1146/annurev.neuro.31.060407.125631 Annu

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Hepatitis delta virus antigens trigger oxidative stress, activate antioxidant Nrf2/ARE pathway, and induce unfolded protein response

The unique feature of this vector is that the amino acid substitution ( AT 87 Q ) allows for high performance liquid chromatography (HPLC) monitoring of the transgene globin levels in the patients cells (Ribeil et al., 2017), with further undergoing studies (ClinicalTrials.gov Identifier: NCT02140554, NCT03282656)