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Semaglutide was added to the 2023 PCOS Treatment guidelines (1) What does this mean clinically
The study would need to disclose the exact formulation, specify the duration of use, define measurable endpoints such as changes in body composition or metabolic rate, and enroll a study population representative of the target consumer
The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]
After 4 weeks of STZ injection, one diabetic group was given saline (vehicle), and the other two were treated with either 1 SEMA (1.44 mg/kg, orally) or 2 SEMA (2.88 mg/kg, orally)