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The role of GLP-1 receptor agonists here is already well established, and many people describe a reduction not just in appetite but in compulsive preoccupation with eating what some have called the quieting of food noise. That matters because it suggests these medications may alter not only consumption but the subjective urgency of craving itself

Neuron 100(6):12921311 Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J (2017) Spinal microglia are required for long-term maintenance of neuropathic pain

Men tend to lose visceral fat first, which means the belly starts flattening before the scale shows dramatic numbers

But reputation alone does not tell researchers what they need to know