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On the other hand, GIPR agonism does reduce food intake in a manner that requires GIPR expression in the CNS 54

In clinical trials, it demonstrated efficacy in enhancing sexual desire and reducing distress associated with HSDD (Kingsberg et al., 2019)

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Additionally, exosomal microRNAs (exomiRs), miRNAs contained in exosomes, play an intriguing role in MAFLD as inter-hepatocellular and inter-organ messengers: exosomes, nanoparticles widely secreted by all cell types, are released into the extracellular space and act as central mediators of intercellular and intra-organ signaling [51, 52], with exomiRs contributing to exosome function and disease diagnosis [53]

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