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Souma, T
Conditions that reduce hepatic blood flow (congestive heart failure, portal hypertension, liver metastases compressing hepatic vasculature) can unexpectedly increase drug exposure even at standard doses
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Hypoxia-induced resistance Immediate effects Hypoxia directly induces the transcription of drug resistance-associated genes, namely MDR1 , MRP1 , and BRCP , which are members of the same ABC transporter family
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