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To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or for voluntary reporting of adverse reactions

To lower the risk of side effects (or to relieve those that may appear), start with a small application and increase gradually over time

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ML226 treatment resulted in HIF-1 stabilization, upregulation of HIF-1 target genes ( CAIX and VEGF ), and activation of a HIF-1 fluorescent reporter (HRE-GFP ODD ) in HeLa cells, similar to treatment with cell-permeable (DM-2OG

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