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Linking metabolic disorders in children and exposure to space hazards Alterations of cell components in Inherited Metabolic Disorders (IMDs) IMDs include more than 1450 extremely rare disorders which are associated with 3.1-fold increased risk of death by 24 h from birth (95% CI 0.8112.19), 27.4-fold increased risk by 28 days (95% CI 18.0741.49), 67.2-fold increased risk by 1 year (95% CI 52.6585.77) and 180.9-fold increased risk by 14 years of age (95% CI 114.41286.13) 2

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