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Clinical trials report 50 to 65% of lost weight returns within 12 months of stopping these medications with meaningful implications for patient expectations and the psychological experience of patients who stop

Participants taking the drug also saw improvements in waist circumference, blood pressure, triglycerides and cholesterol levels

GLP-1 medications work through a completely different biological pathwaythey slow gastric emptying, reduce hunger signals in the brain, and lower blood sugarwhich raises legitimate questions about safety and efficacy when combined with surgical anatomy changes