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In men with a suppressed HPG axis, intermittent or pulsatile GnRH can restore physiological signaling better than continuous exposure

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Conversely, in CRPC, levels of anti-inflammatory cytokines including IL-4, IL-6, and IL-10 are elevated, while TNF- and IL-17 upregulate PD-L1 expression, further intensifying immunosuppression (Wise et al., 2000)

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Once thawed, refrigerate and use within 7 days never refreeze