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Research shows baseline metabolic markers and GLP-1 receptor genetic variants significantly affect treatment response variability across populations

Participant 05 vividly described this as follows: I felt like I had to start gaining weight for them to hear me, to like get out of the struggle

2 Materials and methods 2.1 Model overview The United Kingdom Prospective Diabetes Study Outcome Model version 2.1 (UKPDS OM2) is a validated computerized simulation tool for evaluating the long-term effects of interventions and complications in patients with T2DM, as well as economic outcomes ( 2.2 Simulation population and treatment inputs We utilized patient characteristics and treatments from a network meta-analysis comparing once-daily oral semaglutide 14 mg to injectable GLP-1 RAs in individuals with poorly controlled T2DM on basal insulin

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It also has a $5.2 billion impact on the state budget, including $3 billion less in tax revenue and 165,000 fewer adults in the workforce