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Many authors have suggested that the melanomas, which develop from an existing or pre-existing pigmented lesion usually undergo molecular changes (like melanocytic hyperplasia) induced by chemicals, stress, etc., or can be spontaneous or iatrogenic, before taking the form of an aggressive melanoma

However, its regulatory history under both designations is extensive and requires separate treatment

They may also have a positive effect on lowering the risk of developing diabetes and CVD

Currently, evidence is lacking to introduce many of these therapies into routine practice, though early results are promising

Oxid Med Cell Longev 2012 (PMC3359723) Bertini I et al