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[6] The concern with any unregulated IGF-1R agonist is precisely that it could stimulate the survival and proliferation of pre-neoplastic or neoplastic cells, which is why IGF-1R has been an oncology drug target for inhibition rather than activation

In 2025, Innovent launched Xinermei (mazdutide) in China, and ecnoglutide was launched by Sciwind Biosciences in 2026

The statement along with the petition pose the following questions: Obesity and related diseases, including cardiovascular disease, hypertension, and type 2 diabetes, are leading causes of death in the U.S