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There was no effect on the fertility of rats treated orally with amlodipine maleate (males for 64 days and females for 14 days prior to mating) at doses up to 10 mg amlodipine/kg/day (8 times the maximum recommended human dose 3of 10 mg/day on a mg/m 2basis)

Bone Health Potential : Some studies suggest AOD-9604 may stimulate osteoblasts, hinting at a role in osteoporosis treatment

However, the market faces constraints such as high treatment costs, limited access in lower-income regions, and gastrointestinal side effects which may limit long-term adherence