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If you are of childbearing potential, discuss appropriate contraception with your provider and consider discontinuing semaglutide at least 2 months before a planned pregnancy due to its long half-life

What the research shows: In the landmark STEP clinical trials, patients taking semaglutide lost an average of 15% of their body weight over 68 weeks

Beglinger, S

The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]