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Some possible reasons for this link: the stress of weight stigma creates dysregulation across many physiological systems (including the cardiovascular, metabolic, and the sympathetic and parasympathetic nervous systems), and weight cycling has been shown to create an increased inflammatory response and impaired glucose response in mice

Other recognised side effects include: Injection site reactions (redness, itching, or bruising) Headache and dizziness Fatigue and sleep disturbances Hypoglycaemia (particularly in patients also taking other glucose-lowering medications) Increased heart rate (typically a modest increase of 2-3 beats per minute) Gallbladder disorders , including cholelithiasis Dehydration and potential renal impairment secondary to gastrointestinal effects Serious but rare adverse effects include pancreatitis and severe allergic reactions