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Discussion Our structural and functional analyses reveal that binding of one IGF1 molecule to IGF1R disrupts the -shaped autoinhibited IGF1R dimer and triggers a conformational rearrangement that leads to the formation of an asymmetric -shaped active dimer (Fig
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At skeletal maturity (12 weeks of age), femoral (1.0%) and tibial (1.0%) lengths remained significantly increased on the heat-treated sides [80], suggesting that heat could be a realistic alternative, or at least supplement, to surgical limb lengthening in certain cases
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