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Molecules like glucose, fructose, and galactose stimulate the synthesis of GLP-1 by closing ATP-sensitive K+ channels

Current evidence from clinical trials does not establish a causal relationship between these medications and most cancers in humans, though specific warnings exist for certain tumor types, particularly thyroid cancers, based on animal data

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Notably, chemical chaperones (4-PBA, TUDCA) enhance Gq signaling without reversing this switch, while ER stress-associated UPR factors XBP1 and ATF6 selectively amplify Gs signaling

Gong, B., et al