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3 Adenosyl-B12, on the other hand, is a cofactor for the enzyme converting methylmalonyl-CoA to succinyl-CoA, which is crucial for channelling fatty acids and amino acids into the Krebs cycle for energy production

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Together, these findings identify VadK as a regulatory kinase that integrates metabolic control with virulence in Mtb , revealing a new facet of metabolic regulation in bacterial pathogenesis and a potential target for therapeutic intervention