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The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)
Toxicology , 465 , 153055
The 1 mg dose typically follows the 0.5 mg stage before moving to higher doses like 1.7 mg or 2.4 mg depending on the patients response
The Casey-Fink Readiness for Practice Survey (CFRPS), a valid and reliable survey, was used at the end of each clinical rotation to measure readiness for practice
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