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Not surprisingly, difficulty with side effects was the top reason for discontinuation for over half (51%) of those who stopped their medication

doi: 10.2174/156720206776875902 57 TonnesenMGFengXClarkRA

Fluctuations in intraocular pressure (IOP), insufficient blood supply to the optic nerve, malnutrition, trauma, hypoxia-induced inflammatory responses, and degeneration of RGCs are the basic factors for its onset (123), among which the increase in pathological intraocular pressure (ph-IOP) and the death of RGCs are the key factors (124)

Older adults are at higher risk because thirst sensation already declines with age

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