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This changes the in vivo distribution of the nanoparticle carriers, induces inflammatory responses, disrupts the stability of the formulation, and even triggers hypersensitivity reactions [217]

Enterohepatic circulation further influences LT4 metabolism, with conjugation via glucuronidation and sulfation in the liver, secretion into bile, and partial reabsorption by the intestinal flora (Eghtedari And Correa 2023)

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They provide important support for mechanistic studies and potential therapeutic strategies for muscle-related diseases