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Conclusions Several modifiable factors may optimize the muscle carnosine response to BA supplementation, of which the dose and duration are the strongest known moderators (Figure 2)

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We demonstrate that this effect of a GLP-1R agonist was translationally relevant in human islets through application of a single-cell RNA-Seq (scRNA-Seq) technology, droplet-assisted RNA targeting by single-cell sequencing (DART-Seq) (23), a high-sensitivity scRNA-Seq approach

Follow-up was divided into 8-week intervals after the first dose was dispensed