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Long-term treatment with palmitate, a type of long-chain saturated fatty acid, can disrupt the rhythmic secretion of GLP-1 by suppressing the expression of the Bmal1 clock gene [141]
The SURPASS-3 MRI substudy also showed reductions in liver fat content, VAT, and abdominal subcutaneous adipose tissue at week 52 [62]
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Sustained Weight Loss: Clinical studies have shown that these medications, combined with a balanced diet and regular exercise, can lead to significant and sustained weight loss
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