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This is deeply connected to citrate availability, since citrate is a cataplerotic compound in TCA cycle, which derives from oxaloacetate and acetyl-CoA, but it can also be deviated to feed other metabolic pathways [60, 61]

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The subsequent downstream signaling cascade initiated from substrates of the insulin receptor activates kinases and transcription factors vital in promoting cell metabolism, neuronal growth and differentiation, gene transcription, synaptic plasticity, and neuroprotection [133] (Fig