Conversely, CCK2R is primarily expressed in the brain, particularly in the cortex and the limbic structures including the amygdala, the hippocampus, and the nucleus accumbens 11,12,13,14 and selected regions in the gastrointestinal tract, including gastric epithelial parietal cells 15 , pancreatic acinar cells 16 , myenteric neurons 17 , and human peripheral blood mononuclear cells 18
Common protocols use a loading phase of about 4 to 6 weeks
Participants were trained to self-inject and received periodic retraining during the trial
For example, some sources suggest starting at ~100 mcg for peptides like DSIP, and then adjust only if needed
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