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Since HNMT (the intracellular histamine-degrading enzyme) requires SAMe, impaired methylation can slow histamine clearance, especially in tissues like the brain and airways, where HNMT is the primary clearance pathway

While these serious effects remain rare, anyone with a personal or family history of thyroid cancer should discuss this with their doctor before starting either medication

Along with nausea, many patients also ask how to manage GLP-1 fatigue when balancing treatment and lifestyle

In mouse and rat models of choline and methionine-deficient diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD), females are reported to be more protected than their male counterparts 88

Consistent support makes the process feel more manageable