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Unlike GSH, N-acetylcysteine NAC crosses the blood-brain barrier and might be expected to influence systemic and cerebral GSH levels

The method of any one of embodiments 79-155, wherein the composition further comprises an excipient that decreases the release rate of the therapeutic agent

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However, the CARET trial was terminated because of substantial evidence of harm

Redox Cycling: In the process, GSH is converted to its oxidized form (GSSG) and then regenerated by glutathione reductase, supporting continuous redox cycling