5 Insomnia Difficulty falling or staying asleep , which can affect quality of life and mental and physical well-being
TABLE 1 Characteristics of the deiodinase enzymes activation and inactivation of TH, physiological tissue distribution, and changes in activity in relation to thyroid hormone status D-1 catalyzes inner-ring and outer-ring deiodination, D-2 catalyzes exclusively outer-ring deiodination (activating pathway converting T4 into T3), and D-3 catalyzes only inner-ring mono-deiodination (inactivating pathway)
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