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However, a recent randomized clinical trial in 38 consecutive cirrhotic patients, enrolled within 24 h of an upper gastrointestinal bleed, indicated that OP appeared well tolerated although failed to significantly decrease plasma ammonia at the given doses (10 g/day) [76]

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At the cellular level, glutathione functions as a cofactor for antioxidant enzymes like glutathione peroxidase and glutathione-S-transferase, which neutralize reactive oxygen species and support phase-II detoxification pathways

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