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Availability of data and materials The datasets used and/or analyzed during the current study are available as MS Excel files (.xlsx) and RevMan file (.rm5) from the corresponding author upon reasonable request

These signs of organ dysfunction resolved upon choline reintroduction in the diet

Treatment efficacy can also be monitored by evaluating markers of cuproptosis, which are upregulated before treatment and downregulated following successful therapy [137] , including FDX1, DLAT, lipoic acid synthetase (LIAS), aconitase 2 (ACO-2), succinate dehydrogenase complex iron-sulfur subunit B (SDHB), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1), and dihydropyrimidine dehydrogenase (DPYD)

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