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BCP 157 (0.01 and 10 g/kg, i.p.) decreases the duration of catalepsy and reduces tremor severity in a mouse model of Parkinson's disease induced by MPTP.Formal Name: glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine, acetate
Then, animals received their i.c.v
Nutr Neurosci 19:279283 Tang Y, Li R, Lin G, Li L (2014) PEP search in MyCompoundID: Detection and identification of dipeptides and tripeptides using dimethyl labeling and hydrophilic interaction liquid chromatography tandem mass spectrometry
In vitro studies using endothelial cells stimulated by oxidized low-density lipoprotein (ox-LDL), this compound (10 M, 24 h) increased cell viability, reduced apoptosis from 23% to 19%, inhibited ICAM-1 and E-selectin mRNA expression, and enhanced antioxidant activity through increased superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities while decreasing malondialdehyde (MDA) levels [2]
