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J Mol Cell Cardiol 167:1731 Sawicki KT, Ben-Sahra I, McNally EM (2021) SGLT2 inhibition on cardiac mitochondrial function: searching for a sweet spot

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To sum up, multiple subcellular sites are involved in necroptosis either as signaling hubs frequently acting both upstream and downstream of the RIPK1/RIPK3/MLKL axis forming feedback loops