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Approaches with both preclinical and clinical evidence L-arginine supplementation Rationale L-arginine supplementation to promote NO production is based on the premise that in conditions of endothelial dysfunction, intracellular L-arginine levels may become suboptimal

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Avoid layering peptides with high-strength AHAs or BHAs, strong Vitamin C, retinoids, and low-pH exfoliants, as they may reduce peptide activity and could cause irritation in some cases.